43. Histologic stage is an ordinal categorical variable coded as 1-4 (higher values meaning more advanced progression of disease). Suppose this is initially modeled as a semi continuous variable in a Cox regression, resulting in the following model: In(hazard of mortaility at time t: x)= In().(t)) + 0.8211, where x, =1 to 4 for the four histologic stage levels. The standard error of the slope for x1 ( SE(B,) ) is 0.12. - Based on theses results, what is the estimated hazard ratio of death for patients with a histologic stage of 4 compared to patients with a histologic stage of 1? a. 2.26 b. 6.78 c. 11.50