For a high extraction drug (e.g. metoprolol) administered IV to an elderly subject with reduced hepatic blood flow, which of the following is/are INCORRECT: 

Clearance of metoprolol stays the same because high extraction drugs behave like a low extraction drug when administered IV

Clearance of metoprolol stays the same because high extraction drugs behave like a high extraction drug when administered IV

Clearance of metoprolol is increased because the free fraction is increased

Clearance of metoprolol is increased because the free fraction is decreased

Clearance of metoprolol is decreased because the intrinsic clearance is decreased

Clearance of metoprolol is decreased because the intrinsic clearance is increased

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The detailed answer for the above question is provided below Answer The first answer is INCORRECT Clearance of metoprolol does not stay the same becau... View the full answer