Question: 5. For each drug below: a) Identify acidic, basic and neutral functional groups. b) Identify stereocenters (if any) on each structure. c) Predict water solubility

5. For each drug below: a) Identify acidic, basic and neutral functional groups. b) Identify stereocenters (if any) on each structure. c) Predict water solubility according to Lemke's method. d) At the stomach's pH(1.5), which drugs will be predominantly ionized? e) At the colon's pH(8.0), which drugs will be predominantly ionized? f) Which drugs will remain neutral at both stomach and colon's pH ? g) For each drug. predict at what pH (acidic or basic) the drug will be more water-soluble. h) For each drug, predict at what pH (acidic or basic) the drug will be more lipid-soluble. Estradiol Acetaminophen Phenmetrazine Molindone Carbamatepine Choline ethyl ether Atropine Rameiteen Ibuprofen Renapride CarbaryI Nabumetene Dielotenac Carboprost tromethamine Propanolal Sotalol

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