Question: 6. A CL vs. Va graph is shown below. The star indicates the position of a specific drug on the graph. If the drug discovery

6. A CL vs. Va graph is shown below. The star indicates the position of a specific drug on the graph. If the drug discovery team wants the drug to have a half-life closer to 8 h, what change or changes to the drug should be considered? (10 points) CL (hepafc) vs. Vd 25 1=4h 116=8h 112 = 16 h 20- F= 0.20 15. F:0.40 hepatic CL (mL/min/kg) 10 F=0.60 6 F=0.80 0- 0 5 10 15 20 25 30 35 (kg) 6. A CL vs. Va graph is shown below. The star indicates the position of a specific drug on the graph. If the drug discovery team wants the drug to have a half-life closer to 8 h, what change or changes to the drug should be considered? (10 points) CL (hepafc) vs. Vd 25 1=4h 116=8h 112 = 16 h 20- F= 0.20 15. F:0.40 hepatic CL (mL/min/kg) 10 F=0.60 6 F=0.80 0- 0 5 10 15 20 25 30 35 (kg)

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