[60 Marks] The following compound 1 shows anticancer activity through Tankyrase inhibition. Further work led to the development of a 1-D QSAR equation for structure 2 shown below. R 2 Logl/C -0.398x +1.0890+4.511 OH Propose a workplan that can be used to identify the pharmacophore for 1 (no need to include synthetic detail). Predict the biological activity for 2 where R = OMe, Br, and NO2. Once the researchers on the project identified the pharmacophore for 1 then 3-D QSAR was applied. Describe 3D QSAR and how it can be used to find a new lead structure. (250 words) Structure 3 was identified as the new lead from 3-D QSAR studies. Unfortunately, compound 3 suffered from poor water solubility. Propose a prodrug for 3 that will have enhanced water solubility, include a synthesis for your proposed prodrug and explain how the lead will be released in vivo. [End of Question 2] [60 Marks] The following compound 1 shows anticancer activity through Tankyrase inhibition. Further work led to the development of a 1-D QSAR equation for structure 2 shown below. R 2 Logl/C -0.398x +1.0890+4.511 OH Propose a workplan that can be used to identify the pharmacophore for 1 (no need to include synthetic detail). Predict the biological activity for 2 where R = OMe, Br, and NO2. Once the researchers on the project identified the pharmacophore for 1 then 3-D QSAR was applied. Describe 3D QSAR and how it can be used to find a new lead structure. (250 words) Structure 3 was identified as the new lead from 3-D QSAR studies. Unfortunately, compound 3 suffered from poor water solubility. Propose a prodrug for 3 that will have enhanced water solubility, include a synthesis for your proposed prodrug and explain how the lead will be released in vivo. [End of Question 2]