A bioavailability study (BD) of an antidepressant drug was carried out in healthy volunteers in order to
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Question:
A bioavailability study (BD) of an antidepressant drug was carried out in healthy volunteers in order to compare the sustained-release formulation, the results of which were as follows:
| Time (h) | 1 | 2 | 3 | 4 | 5 | 8 | 12 | 24 | 48 | 72 | 96 |
| Cp (μg/mL) A | 14.8 | 30.9 | 43.5 | 54.3 | 61.3 | 33.6 | 30.4 | 22.4 | 12.2 | 6.6 | 3.6 |
| Cp (μg/mL) B | 9.0 | 13.5 | 18.6 | 23.5 | 28.5 | 31.8 | 30.7 | 25.0 | 15.0 | 10.0 | 6.3 |
Calculate the AUC 0 at infinity and Cpmax for both formulations:
a) Drug A AUC0 to infinity:
b) Drug A CPmax
c) Drug B AUC0 to infinity
d) Drug B Cpmax
e) According to the results of the previous section, which of the two formulations will be the sustained release formula?
f) Calculate the relative BD of B with respect to formulation A
Expert Answer:
Timeh mL A p pgmL 1 148 9 309 135 3 435 186 4 543 235 5 613 285 8 336 318 12 304 307 224 ... View the full answer
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