Question: A gene encoding for the PERK receptor in mice has been knocked out or gets a mutation that leads to non-functional. It is known that

A gene encoding for the PERK receptor in mice has been knocked out or gets a mutation that leads to non-functional. It is known that this protein is required to detect misfolded proteins.

What will be the problem during the quality control of protein?
Is there any bypass to recover this problem?

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