A Glutamate and Lysine residue are surrounded by a cavity of hydrophobic residues. Relative to the p K _a value of the free amino acids, how will the p K _a value of both lysine and glutamate be affected if:

1. They are 10 ? apart in this hydrophobic cavity?
2. They are 4 ? apart in this hydrophobic cavity?
3. They are 4 ? apart on the protein surface instead of a hydrophobic cavity?

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Electrostatic Interactions при HN vir Lysine 08. Glutamic Acid H3N NH Hydrogen Bonding m HN Lysine Ό….... Η Θ H Glutamic Acid -NH H Electrostatic Interactions при HN vir Lysine 08. Glutamic Acid H3N NH Hydrogen Bonding m HN Lysine Ό….... Η Θ H Glutamic Acid -NH H