A large medical center's oncology program reported an increased number of cases of pancreatic cancer during a certain month. The hospital's epidemiologist decided to research the problem. Tumor registry records were searched to identify all cases of pancreatic cancer during a five-year period; cancer patients were matched with patients treated for other diseases during the same five-year period. All subjects in the study were questioned about lifestyle factors including alcohol, tea, and coffee consumption. The resulting data are as follows

Pancreatic Cancer

No Pancreatic Cancer

Total

Alcohol Drinking-Yes

280

140

420

Alcohol Drinking-No

170

410

580

Total

450

550

1000

Which number best approximates or estimates the association of alcohol drinking (yes vs. no) with pancreatic cancer? (Hint: decide what study design was used here and then calculate the most appropriate measure we can calculate in such design)

A.2.27

B.4.82

C.0.41

D.0.21

E.2.44