a) List all four protecting groups on this molecule, and what functional group they are protecting. b)
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Question:
a) List all four protecting groups on this molecule, and what functional group they are protecting.
b) When subjected to hydrogenation over Pd/C catalyst, which two protecting groups are removed?
c) The next step in this synthesis is an intramolecular amide bond formation between the two unprotected groups. Using this fact combined with your previous answers, explain the concept of an orthogonal protecting group strategy.
d) The following text is from the experimental procedure for the intramolecular amide bond formation. If this reaction were to be scaled up for an industrial process, identify two different aspects of this procedure which would not be appropriate on industrial scale.
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