Question: A multicomponent reaction (MCR) process was employed for the preparation of the a-acyl aminocarboxamide 1, a potential lead compound for the development of new anticancer
A multicomponent reaction (MCR) process was employed for the preparation of the a-acyl aminocarboxamide 1, a potential lead compound for the development of new anticancer drugs. a) Identify the common name of this MCR reaction. Draw the four starting materials needed for the synthesis of 1 and suggest appropriate reaction conditions? b) Provide a curly arrow mechanism for the MCR that leads to compound 1. c) Provide reagents and reaction conditions for the two reactions you would use to synthesise 2 starting from 1 (no mechanisms required). Br 2 steps N d) Identify two sites of compound 2 that could be varied to develop a Structure Activity Relation (SAR)
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