A PRO assessment was performed on the four identified risks For each of the risks the estimated cost of mitigating the risk (investment) was determined the enterprise net present value (NPV) protected was calculated given the investment was made and, the investment productivity (a k a return on investment) for each investment was calculated The following table summarizes this information Risk Investment $ (Millions) NPV $ (Millions) Investment Productivity Unreported Adverse Effects 2 120 55 70 FDA Hold for Adverse Effects 15 335 18 65 Delay in Clinical Trial Enrollment 4 550 128 50 Rewrite FDA Submission 3 88 25 10 If the top three most productive investments were approved for implementation, what would be the total investment and how much enterprise value would be protected as measured in NPV

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Question: A PRO assessment was performed on the four identified risks. For each of the risks the estimated cost of mitigating the risk (investment) was determined;

A PRO assessment was performed on the four identified risks. For each of the risks the estimated cost of mitigating the risk (investment) was determined; the enterprise net present value (NPV) protected was calculated given the investment was made; and, the investment productivity (a.k.a return on investment) for each investment was calculated. The following table summarizes this information.

Risk	Investment $ (Millions)	NPV $ (Millions)	Investment Productivity
Unreported Adverse Effects	2	120	55.70
FDA Hold for Adverse Effects	15	335	18.65
Delay in Clinical Trial Enrollment	4	550	128.50
Rewrite FDA Submission	3	88	25.10

If the top three most productive investments were approved for implementation, what would be the total investment and how much enterprise value would be protected as measured in NPV?

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