ACE$-2$ is an enzyme which functions by cleaving a peptide product of the enzyme ACE $($i$.$e$.,$ the two enzymes must function in concert to do their job$).$ It extends beyond the cell, providing a entry point for certain viruses.

SARS$-$CoV spike receptor proteins target this conserved protein. The viral receptor proteins are themselves are likely to $\_\_\_\_\_\_\_\_\_\_\_\_\_\_.$ Evidence for this would include $\_\_\_\_\_\_\_\_\_\_\_\_\_.$

Pick the TWO answers which complete these sentences correctly.

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Group of answer choices

evolve much more slowly than capsid $($external$)$ proteins of the HIV.

if dN$/$dS ratios for the spike proteins are statistically significantly greater than $1.$

if dN$/$dS ratios for the spike proteins are not statistically significantly different from $1.$

evolve at about the same rate as capsid $($external$)$ proteins of the HIV.

if dN$/$dS ratios for the spike proteins are statistically significantly less than $1.$

evolve much more rapidly than capsid $($external$)$ proteins of the HIV.