Question: An article in JAMA by Mandelblatt and colleagues (2002) compared the societal costs and benefits of human papillomavirus (HPV) testing, Pap testing, and their combination

An article in JAMA by Mandelblatt and colleagues (2002) compared the societal costs and benefits of human papillomavirus (HPV) testing, Pap testing, and their combination to screen for cervical cancer. The paper studied 18 different population screening strategies- Pap testing alone, HPV testing alone, and Pap plus HPV testing every 2 or 3 years for women beginning at age 20 and continuing to 65 years, 75 years and death. The table below summarizes some of the results (low cost to high cost) Costs include screening and treatment costs, discounted over the individuals expected lifetime.

Strategy

Cost ($)

QALYs Saved

Incremental cost

Incremental QALY

ICER

  1. No Screening

5,000

26.87

  1. Pap every 3 years to age 75

6,825

27.02

  1. HPV every 3 years to age 75

6,950

27.02

  1. Pap every 2 years to age 75

7,275

27.04

  1. Pap + HPV every 3 years to age 75

7,400

27.04

  1. HPV every 2 years to age 75

7,450

27.04

  1. Pap + HPV every 2 years to age 75

7,925

27.05

  1. Identify all dominant screening strategies. Explain why each is dominant

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