Question: analyze the two substances (Naproxen and hydroxy-Naproxen) with sufficient solution. Now they will be used to analyze the two components from blood samples from patients

analyze the two substances (Naproxen and hydroxy-Naproxen) with sufficient solution. Now they will be used to analyze the two components from blood samples from patients where you can imagine interference from other components, even if we assume that a first sample purification (sample preparation) is done, there may be some extra components that come with the sample. In addition, we can imagine that we do not have such high concentrations of the metabolite depending on the time after taking the tablet that sampling was done. So a detector is needed that is both selective and sensitive. Based on this, discuss which detector principle you would choose to connect to the HPLC system among: (1) UV detector, (2) Fluorescence detector, (3) MS detector. Discuss the pros and cons of all three options and indicate in which order of priority you would choose them and indicate important details such as suitable wavelengths / ion sources, etc.

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