Question: Answer questions a, b and c a) Using suitable examples, identify three ways by which pharmaceutical preparations can undergo degradation during storage and outline how

Answer questions a, b and c three ways by which pharmaceutical preparations can undergo degradation during storage and

a) Using suitable examples, identify three ways by which pharmaceutical preparations can undergo degradation during storage and outline how these pathways can be minimised. (8 marks) b) A drug suspension ( 125mg/mL) decays by zero-order kinetics with a reaction rate of constant of 0.5mg/mL/ hour. What is the concentration of the intact drug remaining after 3 days ( 72 hours) and what is its half-life (t11/2)? ( 8 marks) c) An antibiotic solution has a shelf life of 48 hours at 5C. Using the Q10 approach, calculate the estimated shelf life at 25C ? (4 marks) a) Using suitable examples, identify three ways by which pharmaceutical preparations can undergo degradation during storage and outline how these pathways can be minimised. (8 marks) b) A drug suspension ( 125mg/mL) decays by zero-order kinetics with a reaction rate of constant of 0.5mg/mL/ hour. What is the concentration of the intact drug remaining after 3 days ( 72 hours) and what is its half-life (t11/2)? ( 8 marks) c) An antibiotic solution has a shelf life of 48 hours at 5C. Using the Q10 approach, calculate the estimated shelf life at 25C ? (4 marks)

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