Question: Antibiotic resistance is a growing problem. The antibiotic Vancomycin binds via hydrogen bonding to D-ala-D-ala which is part of an intermediate in Bacterial Cell wall
Antibiotic resistance is a growing problem. The antibiotic Vancomycin binds via hydrogen bonding to D-ala-D-ala which is part of an intermediate in Bacterial Cell wall Biosynthesis. Please indicate all possible hydrogen bond acceptor and donor sites on D-Ala-D-Ala below (Note that D-Ala is just the enantiomer of the naturally occurring amino acid L-Ala.) Bacteria have gain resistance to vancomycin, e.g. vancomycin resistant enteroccoci (VRE), by changing D-Ala-D-Ala to D-Ala-D-Lac where D-lac is D-lactate. Please indicate all possible hydrogen bond acceptor and donor sites on D-Ala-D-Lac below Please indicate how water might hydrogen bond with D-Ala-D-Ala Please indicate how water might hydrogen bond with D-Ala-D-Lac
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