7. As discussed in class tolerance defined as loss of responsiveness to drug can be caused...

 

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7. As discussed in class "tolerance" defined as loss of responsiveness to drug can be caused by many distinct mechanisms. Which of the following would produce tolerance to diazepam, a benzodiazepine that is a positive allosteric modulator of the GABA-A receptor (circle all that apply). a. Decreases in the amount of GABA in the system b. Increases in the amount of GABA in the system c. Decreases in affinity of diazepam d. Increases in affinity of diazepam e. Decreases in affinity of GABA f. Increase in affinity of GABA g. Upregulation of GABA receptors h. Downregulation of GABA receptors i. Changes in the subunit composition of the GABA-A receptors 7. As discussed in class "tolerance" defined as loss of responsiveness to drug can be caused by many distinct mechanisms. Which of the following would produce tolerance to diazepam, a benzodiazepine that is a positive allosteric modulator of the GABA-A receptor (circle all that apply). a. Decreases in the amount of GABA in the system b. Increases in the amount of GABA in the system c. Decreases in affinity of diazepam d. Increases in affinity of diazepam e. Decreases in affinity of GABA f. Increase in affinity of GABA g. Upregulation of GABA receptors h. Downregulation of GABA receptors i. Changes in the subunit composition of the GABA-A receptors

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Drug tolerance shows that your bodys response to a drug over time It occurs when ... View the full answer