Question: Bacteria have gain resistance to vancomycin, e . g . vancomycin resistant enteroccoci ( VRE ) , by changing D - Ala - D -

Bacteria have gain resistance to vancomycin, e.g. vancomycin resistant enteroccoci (VRE), by changing D-Ala-D-Ala to D-Ala-D-Lac where D-lac is D-lactate. Please indicate all possible hydrogen bond acceptor and donor sites on D-Ala-D-Lac below excluding the terminal amine and terminal carboxylic acid
Please indicate how water might hydrogen bond with D-Ala-D-Ala excluding the terminal amine and terminal carboxylic acid.
 Bacteria have gain resistance to vancomycin, e.g. vancomycin resistant enteroccoci (VRE),

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