calculate the elimination rateconstant and half-life of thedrug.

Calculate the volume of distributionof the drug.

The AUC of the drug is 41.5 mg hr/L.Calculate the clearance of the drug

Table 1. Plasma level dataobtained following an I.V. 50 mg bolus dose.

Time, hr	Plasma Concentration, mg/L
0.25	3.0
0.50	2.8
0.75	2.3
1.0	2.2
1.5	2.0
2.0	1.8
4.0	1.4
6.0	1.2
8.0	1.1
15	0.90
22	0.70
30	0.55
36	0.45
48	0.23
60	0.15
72	0.10