Question: can you help me explain this The equilibrium phase is often the longest phase of cancer immunoediting and can last many years. In this phase,
can you help me explain this
The equilibrium phase is often the longest phase of cancer immunoediting and can last many years. In this phase, the cancer cells undergo a period of dormancy, described as a phase of dynamic equilibrium in which tumour outgrowth is suppressed by the immune system. Evidence for equilibrium comes from primary tumorigenesis experiments in which immunocompetent mice were treated with low-dose carcinogens and were found to have occult * cancer cells even though there were no apparent tumours present. When the T cells and IFN-y were depleted in these mice by administering monoclonal antibodies, tumours rapidly appeared at the original site of carcinogenesis injection and were highly immunogenic. Further analysis found that cytokines (e.g., |L-12) and cells (e.g., CD4+ and CD8+ T cells) of the adaptive immune system were responsible for this ia nena neha state of tumour dormancy. Q For your interest, click here to read the article \"Adaptive Immunity Maintains Occult Cancer in an Equilibrium State\" to learn more about the equilibrium phase of cancer. Section 01 | 9of 15Step by Step Solution
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