3. Reconsider the three adrenergic agonists from Q2. Which of the following is an accurate description of the role of CYP2D6 in the metabolism of these molecules? (2 pts) CH OCH3 $ OCH3 CHCHINHC-CHINH, !! OH A HO- HO- OH a. Adrenergic A b. Adrenergic B c. Both adrenergics. OH R -CHUCNH, 1 OH COOH B a. CYP2D6 inactivates adrenergic A by O-dealkylating the o-OCH3 b. CYP2D6 generates an active metabolite of adrenergic A by O-dealkylating the m- OCH3 c. CYP2D6 activates adrenergic B by catalyzing a decarboxylation reaction d. CYP2D6 inactivates adrenergic B by methylating the m-phenol S CHCH-NH2 OH COOH HO- e. CYP2D6 inactivates adrenergic C by catalyzing an N-dealkylation reaction f. CYP2D6 inactivates adrenergic C by oxidizing the primary alcohol to an aldehyde A 4. Stereochemistry challenge: The most potent isomer of the vasoconstrictive adrenergics. drawn below has the same absolute configuration at both asymmetric centers. Which agent requires this stereochemistry for the parent drug to be accepted at the a receptor? (1 pt) -CH-CH2NHCCH, C N OH RS CHOH B CH3 -CHCH-NH-CH3 OH CH3