An oral antiarrythmic drug has the following parameters. . Minimum therapeutic plasma concentration: 0.3 mg/L 60...

 

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An oral antiarrythmic drug has the following parameters. . Minimum therapeutic plasma concentration: 0.3 mg/L 60 mg, 120mg tablets available EM (Extensive metabolizer) PM (poor metabolizer) F (ffp only; fabs-fgut =1) CL (total) (L/h) V (L) CLH (L/h) CLR (L/h) feu (fr) T1/2 (h) 0.75 0.9 50 30 500 500 35 8 ? 1) ? 2) ? 5) ? 3) ? 4) ? 6) ? 7) E 0.25 fb (fu) 0.5 0.5 1)- 7) Fill out the table. 8) Evaluate 120 mg q12h for both EM and PM. Suggest a correct regimen if applicable. 9) If a PM patient has a chronic kidney disease (say, CrCL = 30 mL/min), adjust the dose. An oral antiarrythmic drug has the following parameters. . Minimum therapeutic plasma concentration: 0.3 mg/L 60 mg, 120mg tablets available EM (Extensive metabolizer) PM (poor metabolizer) F (ffp only; fabs-fgut =1) CL (total) (L/h) V (L) CLH (L/h) CLR (L/h) feu (fr) T1/2 (h) 0.75 0.9 50 30 500 500 35 8 ? 1) ? 2) ? 5) ? 3) ? 4) ? 6) ? 7) E 0.25 fb (fu) 0.5 0.5 1)- 7) Fill out the table. 8) Evaluate 120 mg q12h for both EM and PM. Suggest a correct regimen if applicable. 9) If a PM patient has a chronic kidney disease (say, CrCL = 30 mL/min), adjust the dose.

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872 answers 1 CLr renal clearence can be find by Total body clearence Renal clearence Helatic cl... View the full answer