Calculate charged and uncharged ration of weak acid and weak base drug under normal and basic...
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Calculate charged and uncharged ration of weak acid and weak base drug under normal and basic urine pH. What is the effect of urine alkalinization on drug absorption/elimination? What will be the effect for acidic urine? Name 2 agents used to make urine acidic/basic. Weak Acid (pKa = 6.0) Weak Base (pKa = 7.0) !! HA A -NH,= -NH3 3 (1) Normal urine, pH= 6.0 Basic urine, pH= 8.0 2) 4) HA = A -NH, -NH3 Calculate charged and uncharged ration of weak acid and weak base drug under normal and basic urine pH. What is the effect of urine alkalinization on drug absorption/elimination? What will be the effect for acidic urine? Name 2 agents used to make urine acidic/basic. Weak Acid (pKa = 6.0) Weak Base (pKa = 7.0) !! HA A -NH,= -NH3 3 (1) Normal urine, pH= 6.0 Basic urine, pH= 8.0 2) 4) HA = A -NH, -NH3
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Accounting concepts and applications
ISBN: 978-0538745482
11th Edition
Authors: Albrecht Stice, Stice Swain
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