comment on this When you have asked your question (step1)found the evidence (step2) and critically appraised the evidence (step 3) it is time to implement the evidence into practice Below is a list of questions that when answered in relation to a local context, may help you decide whether results from a study can be applied to your practice Is the test affordable, accurate and available in my hospital? Can I estimate the pre-test probability of the disease in question? Will the post-test probability affect my management? Is my patient so different from those in the study group that the results can not be applied? According to the study results, how much would my patient benefit from the treatment? Can the study results be applied to my patient? What is my patient's risk for adverse affects? Are there alternative therapies? Is my patient similar to the patients in the study group? How will the evidence influence my choice of treatment