Question: . Consider the mutation model where A1 u A2 with no back mutations, where u = 10^5. If p [resp. q] denotes the relative frequency

. Consider the mutation model where A1 u A2 with no back mutations, where u = 10^5. If p [resp. q] denotes the relative frequency of A1 [resp. A2] allele, then in the absence of drift and selection p 0 = (1 u)p = (1 u)(1 q) = 1 q u uq = p u uq p = u uq u (if q 0) Let pe 0 denote the approximation of p 0 given by pe 0 = p u Follow the exact and approximate frequencies of the A2 allele for two generations when the initial frequency of A2 is zero and u = 10^5 . What is the relative error introduced by the approximation above?

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