Question: Discuss the alignments, can the sequence difference between the white and red coding sequences be attributed to the difference in the base sequence of ADE1.

Discuss the alignments, can the sequence difference between the white and red coding sequences be attributed to the difference in the base sequence of ADE1.
Identify the type of mutation present in the coding sequence and discuss the implications of the protein.
DNA sequence numbered 60 to 903 (picture 1)n
Protein sequence numbered 60 to 299 (picture 2)n
White coding sequence: White Yeast n
Red coding sequence: red yeast n
n
ADE1: genen
n
Dash marks in the sequence represent deletion or mutation. n
n
Nucleotide and protein changes from comparisons of white and red ADE1

TCGTATCTCT AGAGACATATATGAGGTAGACGCTGGTACGTTGCZGTTGTTGCTACGGATCCTATCTCT 120 WitecodingAD1 RedcodingADE1 GCATATGACGTTATTATGGAA CTATTGACCAAACra 180 GCATATGACGTTATTATGGAAAACAGCA cerGAAAAGGGGATCCTATTGACCAAACTG 180 NitecodingAD1

WhitecodingADE1 RedcodingADE1 ATGTCAATTACGAAGACTGAACTGGACGGTATATTGCCATTGGTGGCCAGAGGIAAAGTT 60 ATGTCAATTACGAAGACTGAACTGGACGGEATAT TTGGTGGCCAGAGGTAAAGET 60 ***** 120 WhitecodingADE1 RedcodingADE1 AGAGACATATATGAGGTAGACGCTGGTACGT TCGTATCTCT AGAGACATATATGAGGTAGACGCTGGTACGTTGCZGTTGTTGCTACGGATCCTATCTCT 120 WitecodingAD1 RedcodingADE1 GCATATGACGTTATTATGGAA CTATTGACCAAACra 180 GCATATGACGTTATTATGGAAAACAGCA cerGAAAAGGGGATCCTATTGACCAAACTG 180 NitecodingAD1 RedcodingADE1 TCAGAGTTCTGGTTCAAGTTCCTGTo ATGITC TTTGGTCGACATCGcC 240 TCAGAGTTCTGGTICAAGITCCTGTcc .CGATGTTCGT ATCATITGGTCGACATCace 240 ...... WhitecodingADE1 RedcodingADE1 CCAGGIAAGACTATTTTCGATTATCTACCTSCAAAATTGAGCGAACCAAAGTACAAAACG 300 CCAGGIAAGACTATTTTCGATTATCTACCTGCAAAATTGAGCGAACCAAAGTACAAAACG 300 WhitecodingADE1 RedcodingADE1 CAACTAGAAGACCGCTCTCTATTGGTICACAAACATAAACTAATTCCATTGGAAGTAATT 360 CAACTAGAAGACCGCTCTCTATTGGTICACAAACATAAACTAATTCCATTGGAAGTAATT *************** 360 NitecodingAD1 RedcodingADE1 GTCAGAGGCTACATCACCGGATCTGCTTGGAAAGAGTACCTAAAAACAGGTACTSTGCAT 420 GTCAGAGGCTACATCACCGGATCTGerrGGAAAGAGTACCTAAAAACAGGTCTSTGCAT 420 WhitecodingADE1 RedcodingADE1 GGTTTGAAACAACCTCAAGGACTTAAAGAATCTCAAGAGTTCCCAGACCAATCTTCACC 480 GGTTTGAAACAACCTCAAGGACTTAAAGAATCTCAAGAGTTCCCAGAACCAATCTTCACc 480 WhitecodingADE1 RedcodingADE1 CCATCGACCAAGGCTGAACAAGGTGAACATGA 540 CATCGACCAAGGCTGAACAAGGTGAACATGACGAA 540 WhitecodingADE1 RedcodingADE1 GAGCTGGTGGGTGAAGATTTGICACGTAGAGTGGCAGAACTGGCTGTAAAACTGTACTCC 600 GAGCTGGTGGGTGAAGATTTGICACGTAGAGTGGCAGAACTGGCTGTAAAACTGTACTCC 600 WhitecodingADE1 RedcodingADE1 AAGTGCAAAGATTATGCTAAGGAGAGGGCATCAT ATCGCAGACACTAAATTCGAATTC 660 AAGTGCAAAGATTATGCTAAGGAGAAGGGCATCATCATCCCAGACACTAAATTCGAATTc 660 ****. WhitecodingADE1 RedcodingADE1 GGTATTGACGAAAAGACCAATGAAATTATTCTAGIGGACGAGGTGCTAACGCCAGACTCC 720 GGTATTGACGAAAGACCAATGAAATTATTCTAGIGGACGAGGTGCTAACGCCAGACTCc 720 ******* **** WitecodingAD1 RedcodingADE1 TCTAGATTCTGGAACGGTGCCTCTTATAAGGTAGGAGAATCCCAAGATTCTTACGATAAG 780 TCTAGATTCTGGAACGGTGCCTCTTATAAGGTAGGAGAATCCCAAGATTCITACGATAAG 780 WhitecodingADE1 RedcodingADE1 CAATTITTAAGAGACTGGCTTACTGCTAATAAGTIGAACGGTGTTAACGGCGT-CAMAAT 839 CAATTITTAAGAGACTGGCCTACTGCTAATAAGTTGAACGGTGTTAGACGGCCTCAAAAT 840 ... ****.. WhitecodingADE1 RedcodingADE1 GCCCCAAGACATTGTCGACAGGACAAGGGCCAAATATATAGAGGCITATGAAACATTGAC 899 GCCCCAAGACATTGTCGACAAAAAAGGGC-CATATATATGGGGC-CCATGAAACATTGAT 898 ************ **** ******** .. ************ WhitecodingADE1 RedcodingADE1 AGGGTCTAAATGGICTCACTAA 921 AGAAA- 903 ..

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