Explain why A & B are correct and why the others are incorrect.

Cefocriptine has the following PK values: F=0.22,fe=0.06,CL=18ml/min/kg,V=40L/kg,TI=1050ng/ml. fu =0.10. Circle all correct statements below. A. Half-life will be sensitive to changes in albumin concentration B. The maintenance oral dosing rate needs to be increased after enzyme induction C. IV administration needs to be lowered after enzyme inhibition D. An iv dose of 100mg will cause toxicity E. Renal disease causing a three-fold increase in the unbound fraction requires a reduction in an oral dosing regimen