Explain why low temperatures are used in the reaction.

- include the possible products that can form if the high temperature was used.

How is deprotonation of the carbonate anion prevented? What reaction conditions were used to prevent this?
 

Transcribed Image Text:

O O (S) (1) 1) 4-methylvaleric acid, THF, Et3N, Pivaloyl NH chloride, 0°c 2) n-BuLi, THF, -78°c step one (S) (2) N O O (S) (1) 1) 4-methylvaleric acid, THF, Et3N, Pivaloyl NH chloride, 0°c 2) n-BuLi, THF, -78°c step one (S) (2) N

Answer rating: 100% (QA)

The low temperatures used in the reaction are likely to prevent unwanted side reactions and to promo... View the full answer