Question: help answer the following question: Question 4: You learned in class that putting active CaMKII into neurons causes long-term potentiation (LTP) as shown below. When
help answer the following question:
Question 4: You learned in class that putting active CaMKII into neurons causes long-term potentiation (LTP) as shown below. When CaMKII is denatured by heat, it does not produce LTP, as shown in the graph. 200- Active CaMKII Synaptic strength (%) 100 + Heat denatured CaMKII 1 hour Time You also learned that CaMKII and NMDA receptors can form liquid-liquid phase separation (LLPS). This is the result that was shown in class. (Remember: GluN2B is a subunit of NMDA receptor; WT = wildtype protein; CaMKII mutations listed are kinase-dead mutations Kinase-dead mutations Mutations that prevent binding unable to maintain unable to form CaMKII: WT K42R T286A 1205K 1-314 WT WT GluN2B: WT WT WT WT WT LR-AQ RS-QD O Ca2+ Cat- EGTA (EGTA: Ca2+ chelator) Current Opinion in NeurobiologyStep by Step Solution
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