Henry et al$.($E$7)$ conducted an investigation to determine whether experimentally

induced pulmonary embolism in animals without underlying heart disease consistently leads to alterations in serum creatine phosphokinase $($CPK$)$ activity. They produced experimental pulmonary embolism in conscious mongrel dogs by injecting whole blood or plasma clots directly into the left main pulmonary artery. They measured serum CPK during the control period and serially after induction of pulmonary embolism. Their results are shown in Table $7\mathrm{.}17.$ Test the null hypothesis of no change in CPK activity against the alternative that it increases with time up to $120$ minutes. What is the P$-$ value?

Table $7\mathrm{.}17$

Dog

Before embolization

After embolization, minutes

$15$

$60$

A

$28$

$97$

$126$

$158$

$48$

B

$23$

$45$

$48$

C

D

$26$

$22$

$87$

$97$

$24$

$32$

$33$

E

$25$

$120$

$68$

$60$