Imagine you are tasked with designing a bridge spanning a wide river in a region prone to earthquakes. Discuss the key considerations you would take into account during the design process to ensure the structural integrity and resilience of the bridge against seismic events. Include aspects such as material selection, structural design principles, foundation types, and any innovative techniques or technologies you might incorporate to enhance the earthquake resistance of the bridge. Additionally, consider how you would assess and mitigate potential risks associated with liquefaction and soil instability in the bridge's vicinity during seismic events. Provide a comprehensive overview of your approach, highlighting the interconnectedness of various engineering disciplines involved in such a project.