Question: In applying the retinol isotope dilution (RID) method, specific activity in plasma (SAP) is defined as the proportion of isotope-labelled retinol to total retinol in
In applying the retinol isotope dilution (RID) method, specific activity in plasma (SAP) is defined as the proportion of isotope-labelled retinol to total retinol in the plasma. The SAP for two research participants is below. Both participants received a dose of 500 g isotope-labelled retinol. Both participants absorbed the dose well. Given what you know about the physiological basis for the RID test, which participant is likely to have higher vitamin A stores (1 or 2)? Participant: _____________ Participant SAP 1 0.069 2 0.045 c) In another study, the RID method is applied to estimate total body vitamin A stores of an 8-month-old infant. However, when the researcher administers the stable isotope dose, she accidentally administered double the dose appropriate for an infant. If this child continues through the RID assessment, how would this event affect the child's SAP measurement (circle one)? Increase Decrease No change How would this affect the measurement of vitamin A stores (circle one)? Underestimate Overestimate No change
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