In the realm of structural engineering, consider the theoretical implications of designing a skyscraper that stretches into the mesosphere, far beyond the conventional heights of today's tallest buildings. Discuss the challenges such a structure would face in terms of material strength, foundation design, wind loading, and potential impacts on the surrounding environment. How might advancements in materials science and construction techniques facilitate such a feat, and what theoretical limits might still constrain the realization of such a megastructure?