$k\frac{J}{m}ol2\%G_{\text{b}\text{i}\text{n}\text{d}}=-33\mathrm{.}6k\frac{J}{m}ol298\mathrm{.}15K50\%D,[D{]}_{\text{t}\text{o}\text{t}}50\%E2\%D50\%E[D{]}_{\text{t}\text{o}\text{t}}=1\mathrm{.}43{10}^{-6}mo\frac{l}{\frac{?}{?}}T=298\mathrm{.}15K.$

Part $A-$ Binding free energy

What $is$ the binding free energy for the formation $of$ the complex $ED?$ Provide your answer $in$ units $ofk\frac{J}{m}ol$ and with $3$ significant figures.

The margin $of$ error $is2\%.$

The binding free enery for the complex $EDis{G}_{\text{b}\text{i}\text{n}\text{d}}=-33\mathrm{.}6k\frac{J}{m}ol$

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Correct

This binding free energy corresponds $to-13\mathrm{.}5$ times $RTat298\mathrm{.}15K.$

Part $B-$ binding $50\%of$ the drug target

Which total concentration $of$ the drug $D,[D{]}_{\text{t}\text{o}\text{t}},is$ needed $to$ bind $50\%of$ the drug target enzyme $E$ into the complex $ED?$ Provide your answer $in$ units $ofmo\frac{l}{a}nd$ with $3$ significant figures.

The margin $of$ error $is2\%.$

View Available Hint$(s)$

The total concentration $of$ the drug $D,$ required $to$ bind $50\%of$ the drug target enzyme $E,is[D{]}_{\text{t}\text{o}\text{t}}=1\mathrm{.}43{10}^{-6}mo\frac{l}{\frac{?}{?}}$

Correct

$2\%\frac{D}{ED}=10\mathrm{.}4$DED$2\%K_{D}E{D}^{\text{'}}1\mathrm{.}88{10}^{-8}E50\%D^{\text{'}}D$

$3of3$

$3$ significant figures.

The margin $of$ error $is2\%.$

The ratio $of$ concentrations $\frac{D}{ED}=10\mathrm{.}4$

Correct

This means that for every molecule $D$ forming a complex with the drug target $E,$ there are $10\mathrm{.}4$ molecules $ofD$ that are not participating $in$ complex formation.

Part $D-$ Improving the drug

The margin $of$ error $is2\%.$

The dissociation constant $K_D$ for the complex $E{D}^{\text{'}}is1\mathrm{.}88{10}^{-8}$

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Correct stabilization $of$ the complex $ED\text{'}$ resulted $in$ a reduction $of$ the dissociation constant $by$ almost two orders $of$ magnitude!

Part $E-$ binding $50\%of$ the drug target with $D^{\text{'}}$

$D^{\text{'}}{D}^{\text{'}},[D{]}_{\text{t}\text{o}\text{t}}50\%\frac{E}{2}\%D^{\text{'}}50\%E[D{]}_{\text{t}\text{o}\text{t}}=1\mathrm{.}44{10}^{-7}mo\frac{l}{?}{D}^{\text{'}}\frac{D}{ED}=50\%of$ the drug target with $D^{\text{'}}$

Which total concentration $of$ the drug $D^{\text{'}},[D{]}_{\text{t}\text{o}\text{t}},is$ needed $to$ bind $50\%of$ the drug target enzyme $E$ into the complex $ED?$ Provide your answer $in$ units $ofmo\frac{l}{\frac{?}{?}}$ and with $3$ significant figures.

The margin $of$ error $is2\%.$

The total concentration $of$ the drug $D^{\text{'}}$ required $to$ bind $50\%of$ the drug target enzyme $Eis[D{]}_{\text{t}\text{o}\text{t}}=1\mathrm{.}44{10}^{-7}mo\frac{l}{?}$

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Correct

Part $F-$ Effectivity $of$ the drug $D^{\text{'}}$

The ratio $of$ concentrations $\frac{D}{ED}=$

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REALLY NEED HELP WITH PART F