Manhattan plots in GWAS studies $($such as that shown below$)$ often show a series of SNPs in

close physical proximity in the genome that all exceed statistical significance and create a

GWAS "peak" that gives the impression of skyscrapers on the Manhattan skyline. What is the

best explanation for this phenomenon?

GWAS "peaks" represents multiple tightly$-$linked SNPs that each contribute to

the causality of disease

GWAS "peaks" represent a series of tightly$-$linked SNPs in linkage disequilibrium with a

mutation that contributes to the causality of disease

GWAS "peaks" are tightly linked SNPs in a mutation hotspot that inflate nucleotide

diversity

GWAS "peaks" represents regions with ancestral haplotypes showing elevated levels of

ibentity$-$by$-$descent