Milling is a unit operation to control the particle size by transforming solid particles into smaller ones
Question:
Milling is a unit operation to control the particle size by transforming solid particles into smaller ones by applying forces such as shear, compression, friction, collision, or impact. The bead mill is an apparatus that agitates the beads in a cylindrical vessel to disperse minute particles in a slurry. The motion of the bead induces shear and impact on the particles. One of the major factors affecting the particle size is the size and material of bead chosen for milling. It affects the frequency of impact between the bead and the final particle size to be achieved. Fine drug particles are especially desired in formulations designed for parenteral, respiratory and transdermal use.
In this case study, contestants are tasked with optimizing the milling operation, particularly selecting the material of bead, duration of operation and shaft kinetics.
Additionally, they need to address challenges related to process scalability, transfer limitations, formulation considerations, product stability and contamination risks control. Moreover, researching literature for valuable insights and potential solutions will be critical to devising an efficient and effective milling process.
For the detail provided below:
Slurry A with initial viscosity 5mPa.s, and, below details:
Smith and Roberson Business Law
ISBN: 978-0538473637
15th Edition
Authors: Richard A. Mann, Barry S. Roberts