need help with this question

The pedigrees below show data on multiplex disease families with data at one multi allelic marker (alleles are a, b, c, d, e). Assume that the disease f ollows an autosomal dominant model. Assume for this part that the disease is fully penetrant (P(disease | MM or Mm) = 1) and there are no phenol c opies (P(disease | mm) = 0), where M and m are the alleles at the disease locus, (a) Which families are phase known (the parental generation phase can be determined)? (b) Explain why non-diseased parents are not informative for linkage. (c) For pedigrees 1 and 3, determine the number of recombinants and nonrecombinants. Find the ML of 0 based on these 2 pedigrees. (d) For pedigree 4, what is the LOD score for 0 = 0? What would it be if the last offspring were bc rather than bb? (e) Write out the likelihood for pedigree 2 as a function of 0 and find the ML of 0. What is the LOD at the ML? Now assume that the phase of the affec ted mother is known to be Md/mc. What is the ML of 0 and the LOD at 0, and LOD at 0 = 12. Comment on the effect of not knowing phase. (f) Suppose we assume incomplete penetrance, so that P(disease | Mm, MM) = f , o