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BP13
Gleevec is designed to inhibit the Abl by displacing its natural substrate ATP. It is known that the mutant binds ATP with an affinity of 0.01 mM (_) and ATP concentration is 0.2 mM. The actual affinity of Gleevec for Abl (_) is 1 nM. At what concentration of Gleevec (_50), would 50% of Abl be inhibited?

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