Once the guide RNA binds to the complement of the target DNA sequence, it activates the nuclease activity $($DNA$-$cutting ability$)$ of the Cas$9$ enzyme. Cutting DNA is also called $$cleaving$.$ Cas$9$ always cleaves both strands of DNA. It cleaves both the target DNA and its complement three nucleotides upstream $($toward the $5$ end$)$ of the PAM sequence. $6.$ Rewrite the target DNA sequence and its complement below, indicating where Cas$9$ would cut both strands of DNA with a large space or vertical line $(|).$