1. In your own words, explain why we do toxicity testing: 2. Give an example of...

  

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1. In your own words, explain why we do toxicity testing: 2. Give an example of a toxic chemical substance for each of the following categories: Abiotic toxicant Biotic toxicant Xenobiotic toxicant 3. Understanding Dose vs Exposure John works applying pesticide X to agricultural fields. He spent the morning cleaning out a tank that had contained concentrated pesticide X. The tank was large and he was standing in water all morning (4 hours) power washing the tank. Human skin is a wonderful barrier to entry of compounds as long as it is dry and intact, but wet wrinkly skin can absorb toxins. About 5% of pesticide X absorbs into wet skin and John was in contact with water that had a total of 32 g of the pesticide in it. After the morning is over, John has lunch but does not wash his hands; he has 2 g of the pesticide on his hands. Pesticide X has about 90% absorption from an oral dose. Finally, John works in the field in the afternoon a crop plane flies over dusting the crops with pesticide X, the air he breathes in has a total of 5 grams of the compound in it. Pesticide X is known to have absorption of about 50% through inhalation. What is John's exposure to Pesticide X and what is his dose? Exposure (grams) Route of Exposure Dose (grams) Dermal Oral Inhalation Total Looking at the total exposure and dose, what percentage of his exposure that was a dose? 4. Explain four methods of obtaining data and information about the potential adverse health impacts of xenobiotic chemicals for humans. 1. In your own words, explain why we do toxicity testing: 2. Give an example of a toxic chemical substance for each of the following categories: Abiotic toxicant Biotic toxicant Xenobiotic toxicant 3. Understanding Dose vs Exposure John works applying pesticide X to agricultural fields. He spent the morning cleaning out a tank that had contained concentrated pesticide X. The tank was large and he was standing in water all morning (4 hours) power washing the tank. Human skin is a wonderful barrier to entry of compounds as long as it is dry and intact, but wet wrinkly skin can absorb toxins. About 5% of pesticide X absorbs into wet skin and John was in contact with water that had a total of 32 g of the pesticide in it. After the morning is over, John has lunch but does not wash his hands; he has 2 g of the pesticide on his hands. Pesticide X has about 90% absorption from an oral dose. Finally, John works in the field in the afternoon a crop plane flies over dusting the crops with pesticide X, the air he breathes in has a total of 5 grams of the compound in it. Pesticide X is known to have absorption of about 50% through inhalation. What is John's exposure to Pesticide X and what is his dose? Exposure (grams) Route of Exposure Dose (grams) Dermal Oral Inhalation Total Looking at the total exposure and dose, what percentage of his exposure that was a dose? 4. Explain four methods of obtaining data and information about the potential adverse health impacts of xenobiotic chemicals for humans.

Answer rating: 100% (QA)

1 We do toxicity testing just to understand that how does a toxic substance do damage any living or nonliving organisms its also used for the drug development process These tests are helpful to grasp ... View the full answer