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Note to Instructors John Styles, founder of the Styles Company, was afforded an opportunity by the CFO of M. D. Anderson Cancer Center in Houston, Texas, to partner with Anderson in financing, constructing, and managing a proton cancer therapy center in that city. The primary reasons for considering the construction of the center were that Anderson could not handle the high demand for radiation therapy that they were experiencing in the early years of the twenty-first century, and additionally, proton therapy was a much more refined and effective method of treating some types of cancer than other traditional radiation therapies. The site plan for the proton cancer therapy center estimated that approximately 92,000 square feet would be needed for the facility to house state-of-the-art equipment that had not yet been approved by the Federal Drug Administration. The cost of the project was estimated to be $100 million, and the primary constraint in raising money was the fact that it would take several years to complete the deal and build the center. Therefore, payback on the investment would not begin until patients were treated in the facility which would be as long as five or more years. The focus of the case is the decision that John Styles had to make on whether or not he and his company should enter into a partnership with M. D. Anderson Cancer Center to build a Proton Cancer Therapy Center in Houston, Texas. In assessing the wisdom of undertaking this project, Styles had to consider many of the risks identified in the research of Monroy and Folger (1993). The key issues and discussion points of this case include the following: Potential Audience and Uses This case was developed for use in an undergraduate or graduate course in entrepreneurship or small business to illustrate the complexity of the decision-making process for an entrepreneur in considering a new project. In this case, the entrepreneur faced the dilemma of whether or not to undertake securing the financing, construction, and management of a new cancer center in Houston, TX. The case would work well in an early session of the course when characteristics, motivation, and decision processes of entrepreneurs are being discussed. Required: a) Assess the pros and cons of entering into the proton cancer therapy center deal. b) Analyze the sources of funding available for new ventures and their applicability to the proton center cancer therapy center. c) Outline a deal to approach likely investor groups about the proton cancer therapy center