please calculate these ratios :

1- Rate if return in investment (ROE)

2- P/E ratio

3- Debit to equity ratio

4- The ratio of interest to total assets

5- Ratio due flux de tresorerie

Annual Data I Millions of US \$ except per share data 20221231 Revenue Cost Of Goods Sold Gross Profit Research And Development Expenses Annual Data I Millions of US S except per share data Revenue Cost OI Goods Sold Gross Profit Research And Developenent Expenses SG8A Expenses Other Operating income Or Expenses Operating Expenses: Operating Income Total Non-Operating Income/Expense Pre-Tax income Income Taxes Income After Taxes Other lncome Income From Continuous Operations Annual Data I Millions of US S except per share data 2022123120211231202012312019123120181231 Cash On Hand Receivables Inventory Pre-Paid Expenses Other Current Assets Total Current Assots Property. Plant, And Equipment LhelLhel$146,791$186,715$161,580$160,281$132,733$113,114$96,334$72,705$75,101$61,797 Long-Term Investments Goodwill And Intangible Assets Other Long- Term Assets Total Long-Term Assete Total Assets Total Cument Liabilities Long Term Dobt Other Non-Current Liabilities Total Long Term Liabilites Total Liabilities Common Stock Net Retained Earnings (Accumulated Deficit) Comprehensive Income Other Share Holders Equity Share Holder Equity Total Liabilities And Share Holders Equity Annual Data I Millions of US \$ except per share data 20221231 Revenue Cost Of Goods Sold Gross Profit Research And Development Expenses Annual Data I Millions of US S except per share data Revenue Cost OI Goods Sold Gross Profit Research And Developenent Expenses SG8A Expenses Other Operating income Or Expenses Operating Expenses: Operating Income Total Non-Operating Income/Expense Pre-Tax income Income Taxes Income After Taxes Other lncome Income From Continuous Operations Annual Data I Millions of US S except per share data 2022123120211231202012312019123120181231 Cash On Hand Receivables Inventory Pre-Paid Expenses Other Current Assets Total Current Assots Property. Plant, And Equipment LhelLhel$146,791$186,715$161,580$160,281$132,733$113,114$96,334$72,705$75,101$61,797 Long-Term Investments Goodwill And Intangible Assets Other Long- Term Assets Total Long-Term Assete Total Assets Total Cument Liabilities Long Term Dobt Other Non-Current Liabilities Total Long Term Liabilites Total Liabilities Common Stock Net Retained Earnings (Accumulated Deficit) Comprehensive Income Other Share Holders Equity Share Holder Equity Total Liabilities And Share Holders Equity