Please select the correct answer $($five points$).$

Herceptin, an anti$-$HER$2$ monoclonal antibody used for treating breast and other cancers:

acts by inducing apoptosis, enhancing Tregs and blocking through these and other mechanisms tumor growth and metastasis;

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acts through ADCC and induces the production of IL$-17,$ IL$-23$ and TGF$-$beta;

does not interfere with the dimerization of the epidermal growth factor receptor, but blocks tumor cell proliferation, tumor growth and metastasis by upregulating the expression of Her$-2$;

acts through ADCC, by depleting Tregs and by downregulating human epidermal$-$ growth$-$factor$-$like receptor $2($HER$2).$