Question: please write a balanced reaction and calculate the theoretical yield. Dissolve 1.00 g (0.007 mol) of 2-sulfanylidene-1,2-dihydropyridine-3-carbonitrile 2 in 8-10 mL of N,N- dimethylformamide to
please write a balanced reaction and calculate the theoretical yield.
Dissolve 1.00 g (0.007 mol) of 2-sulfanylidene-1,2-dihydropyridine-3-carbonitrile 2 in 8-10 mL of N,N- dimethylformamide to give an opaque yellow solution. Add 5.6 mL of 10% potassium hydroxide. The resulting mixture should be a clear yellow solution. Stir reaction mixture at room temperature and add 0.47 mL (0.007 mol) of 2-chloroacetonitrile dropwise. This reaction is exothermic, and a precipitate can form almost immediately. . Second portion of 5.6mL of 10% potassium hydroxide solution should be added once alkylation confirmed by TLC. While still stirring, heat the reaction mixture to 60oC and stir for 15-20 minutes. After confirmation of cyclization via TLC, cool reaction mixture to room temperature and add about 10 mL of ice-cold water.
Step by Step Solution
There are 3 Steps involved in it
Get step-by-step solutions from verified subject matter experts
