Q$2.(10$ pts$)$ Your collaborator sends you the new crystal structure they have of the Active Site of Glucokinase, an enzyme that has a $100-$fold lower affinity for glucose $(C_6{H}_{12}{O}_6)$ than a related enzyme, Hexokinase. Importantly, both enzymes have the same catalytic amino acids. She performed her experiment in both the absence and presence of glucose:

D$-$Glucose

A$.$ What amino acid or acids are likely involved in substrate binding in this diagram? How would you change these amino acids to make glucokinase bind to glucose better?.