Q.4. A pharmaceutical company set up a small batch process in order to manufacture 500 tablets containing a drug for the control of cholesterol. The formulation of these tablets began by adding the API and 25g of an excipient to a crusher, and then to a kneader. Another stream of excipients consisting of 91 \% liquid by mass was added to the kneader. The kneader produced a wet cake which was spread over trays and kept in an oven at 48C for 10 hours. During this time, 17 mass % of the cake evaporated. The dried cake was blended with a lubricant and a binder, and compressed into tablets. Each tablet had a total mass of 100mg. The tablets had the following composition: 21 mass \% API, 52 mass \% excipients, 26 mass \% binder and the remainder was a lubricant. (a) Copy the flowchart into your answer book and finish labelling it. (4 marks) (b) Calculate the mass of lubricant that was added to the blender. (11 marks) (c) Calculate the mass of liquid that was added to the kneader. (15 marks) Q.4. A pharmaceutical company set up a small batch process in order to manufacture 500 tablets containing a drug for the control of cholesterol. The formulation of these tablets began by adding the API and 25g of an excipient to a crusher, and then to a kneader. Another stream of excipients consisting of 91 \% liquid by mass was added to the kneader. The kneader produced a wet cake which was spread over trays and kept in an oven at 48C for 10 hours. During this time, 17 mass % of the cake evaporated. The dried cake was blended with a lubricant and a binder, and compressed into tablets. Each tablet had a total mass of 100mg. The tablets had the following composition: 21 mass \% API, 52 mass \% excipients, 26 mass \% binder and the remainder was a lubricant. (a) Copy the flowchart into your answer book and finish labelling it. (4 marks) (b) Calculate the mass of lubricant that was added to the blender. (11 marks) (c) Calculate the mass of liquid that was added to the kneader. (15 marks)