Refer to the table below.

This is a hypothetically group presentation assignment. We've chosen the drug highlighted in green on the table below for the following reasons: We recommend MiRo 22-709A for clinical testing as it is best for oral administration and low toxicity. 51% inhibition for its target enzyme. It has high GI absorption, can permeate BBB, does not have P-gp substrate, does not have any Lipinski violations and has high ionisation percentages at 5 8 pH. The other compounds dont meet one or more of the previously mentioned criteria. So for the selected pre-clinical drug candidate.

Please explain how many stereoisomers are possible (four) and how does it bind to the target? (the target enzyme being ACHe - Acetylcholinesterase) this is for a speech so just speak about those two aspects related to the chosen drug of choice and how it binds to the target. Please mention hydrogen bonding if you can. Thank you in advance. Will rate well for good answer. Four stereoisomers are (R,R)-MiRo 22-709A

(R,S)-MiRo 22-709A

(S,R)-MiRo 22-709A

(S,S)-MiRo 22-709A

Table 3: Calculated and predicted properties the original hit, MiRe 22-401T, and three significant optimised leads.

Table 3: Calculated and predicted properties the original hit, MiRe 22-401T, and three significant optimised leads