Question: Robinson Annulation - Practice Compound 1 is a key intermediate in the synthesis of female hormone estrone. Draw the starting materials A and B needed
Robinson Annulation Practice
Compound is a key intermediate in the synthesis of female hormone estrone. Draw
the starting materials A and needed to synthesize it by a Robinson annulation:
Identify the double bond formed at the final step of the annulation.
Identify the position of the carbonyl group which underwent nucleophilic addition
with enolate.
Identify the structure of the second enolate formed during the annulation.
Identify the site of initial Michael addition.
Draw the structures of A and
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