Question: Select the FALSE statement about Tay - Sachs disease : GM 2 gangliosidoses are progressive neurodegenerative disorders caused by loss - of - function mutations

Select the FALSE statement about Tay-Sachs disease :
GM2 gangliosidoses are progressive neurodegenerative disorders caused by loss-of-function mutations in any of the genes HEXA (15q23), HEXB (5q13) or GM2A (5q33).
Hexosaminidase A and its associated GM2 activator protein are found in most tissues, but their deficiency causes severe swelling and cell death only in neurons.
Individuals from high-risk populations (carrier frequencies ca.1/30), or with a family history of Tay-Sachs disease, can learn their carrier status from serum screening for hexosaminidase A, followed by DNA sequencing if the serum activity is low.
Infants of parents who are both carriers of a null allele of HEXA have a prior risk 1/4 of Tay-Sachs disease. Prenatal testing can be used to decide whether to continue (normal & carrier) or terminate (affected) the pregnancy. Where legal, elective abortion has reduced the incidence of Tay-Sachs disease in high-risk communities by as much as 90%.
Prenatal testing cannot reliably predict the occurrence, or the severity of Tay-Sachs disease.
During their first few months, Tay-Sachs infants develop normally.

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